Anti-Galectin 3/LGALS3 Antibody Picoband® Fluoro488 Conjugated

Galectin-3 (GAL3), also known as LGALS3, MAC2 or GALBP, is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is encoded by a single gene, it located on chromosome 14, locus q21– q22. It is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space. Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and Ventricular remodeling. Galectin-3 is expressed in various tissues and organs, but is significantly absent in normal hepatocytes.

Galectin-3; Gal-3;35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; IgE-binding protein; L-34 galactoside-binding lectin; Laminin-binding protein; Lectin L-29; Mac-2 antigen; Lgals3

E.coli-derived mouse Galectin 3 recombinant protein (Position: K153-I264) . Mouse Galectin 3 shares 88% and 91% amino acid (aa) sequence identity with human and rat Galectin 3, respectively.

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity) . .

1. Dumic J, Dabelic S, Flögel M. (2006) . Galectin-3: an open-ended story.. BBA General Subjects 1760 (4) : 616–635. 2. Liu F, Patterson RJ, Wang JL. (2002) . Intracellular function of galectins.. BBA General Subjects 1572 (2-3) : 263–273. 3. Cooper D. (2002) . Galectinomics: finding themes in complexity.. BBA General Subjects 1572 (2-3) : 209–231. 4. Raimond J, Zimonjic DB, Mignon C, et al. (1997) . Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21—22.. Mamm. Genome 8 (9) : 706–707.