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Anti-Neuropeptide Y/NPY Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.

Synonyms

Pro-neuropeptide Y; Neuropeptide Y; Neuropeptide tyrosine; NPY; C-flanking peptide of NPY; CPON; NPY

Gene Name

NPY

Gene ID

4852

UniProt

P01303

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Neuropeptide Y, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Applications

Flow Cytometry

Field of Research

Biochemicals, Chemical Type, Neuropeptides, Neuroscience, Neurotransmitter, Obesity

Purification

Immunogen affinity purified.

Form

Liquid

Function

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

References & Citations

1. Benarroch, E. E. Neuropeptide Y: its multiple effects in the CNS and potential clinical significance. Neurology 72: 1016-1020, 2009. 2. Lee, E. W., Michalkiewicz, M., Kitlinska, J., Kalezic, I., Switalska, H., Yoo, P., Sangkharat, A., Ji, H., Li, L., Michalkiewicz, T., Ljubisavljevic, M., Johansson, H., Grant, D. S., Zukowska, Z. Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. J. Clin. Invest. 111: 1853-1862, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

10851 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pro-neuropeptide Y

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the NPY family.

Protein Name

Pro-neuropeptide Y

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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