Anti-P2X2/P2RX2 Antibody Picoband®

The P2RX2 gene encodes the P2X2 receptor, which assembles as a trimer to form a ligand-gated ion channel gated by extracellular ATP. P2X2 receptors mediate a variety of cellular responses, including excitatory postsynaptic responses in sensory neurons. The product of this gene belongs to the family of purinoceptors for ATP. P2RX2 is mapped to 12q24.33. It has been found that ATP-activated P2RX2 influenced OHC electromotility, a stimulus-induced change in hair cell length that functions as an amplifier to determine hearing sensitivity and frequency selectivity. What’s more, P2RX2 channels were necessary for development of the temporary threshold shift.

E.coli-derived human P2X2 recombinant protein (Position: D139-L471) . Human P2X2 shares 84% amino acid (aa) sequence identity with both mouse and rat P2X2.

Cancer, Cancer Metabolism, Ligand-Gated Ion Channels, Metabolism, Metabolism Processes, Neuroscience, Neurotransmission, Pathways and Processes, Receptors / Channels, Response To Hypoxia

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K (+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. .

1. Housley, G. D., Morton-Jones, R., Vlajkovic, S. M., Telang, R. S., Paramananthasivam, V., Tadros, S. F., Wong, A. C. Y., Froud, K. E., Cederholm, J. M. E., Sivakumaran, Y., Snguanwongchai, P., Khakh, B. S., Cockayne, D. A., Thorne, P. R., Ryan, A. F. ATP-gated ion channels mediate adaptation to elevated sound levels. Proc. Nat. Acad. Sci. 110: 7494-7499, 2013. 2. Yan, D., Zhu, Y., Walsh, T., Xie, D., Yuan, H., Sirmaci, A., Fujikawa, T., Wong, A. C. Y., Loh, T. L., Du, L., Grati, M., Vlajkovic, S. M., and 10 others. Mutation of the ATP-gated P2X (2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc. Nat. Acad. Sci. 110: 2228-2233, 2013. 3. Yu, N., Zhao, H.-B. ATP activates P2x receptors and requires extracellular Ca (++) participation to modify outer hair cell nonlinear capacitance. Pflugers Arch. 457: 453-461, 2008.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.