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Anti-P2X5/P2RX5 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

P2X purinoceptor 5 is a protein that in humans is encoded by the P2RX5 gene. The product of this gene belongs to the family of purinoceptors for ATP. It has been identified that the P2RX5 gene within a BAC contig covering chromosome 17p13. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Quantitative dot blots revealed that P2X5R expression is highest in brain and immune system and is developmentally regulated.

Synonyms

P2X purinoceptor 5; P2X5; ATP receptor; Purinergic receptor; P2RX5; P2X5

Gene Name

P2RX5

Gene ID

5026

UniProt

Q93086

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human P2X5 recombinant protein (Position: D333-T422) . Human P2X5 shares 42% amino acid (aa) sequence identity with rat P2X5.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in brain and immune system.

Applications

Flow Cytometry

Field of Research

Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for ATP that acts as a ligand-gated ion channel.

References & Citations

1. Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5 2. Le, K.-T., Paquet, M., Nouel, D., Babinski, K., Seguela, P. Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett. 418: 195-199, 1997. 3. Touchman, J. W., Anikster, Y., Dietrich, N. L., Maduro, V. V. B., McDowell, G., Shotelersuk, V., Bouffard, G. G., Beckstrom-Sternberg, S. M., Gahl, W. A., Green, E. D. The genomic region encompassing the nephropathic cystinosis gene (CTNS) : complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.Genome Res. 10: 165-173, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

47205 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

P2X purinoceptor 5

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the P2X receptor family.

Protein Name

P2X purinoceptor 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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