Anti-Profilin 1/PFN1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Profilin-1 is a protein that in humans is encoded by the PFN1 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. PFN1 is mapped to 17p13.2. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. This gene is a 140-amino acid protein and major growth regulator of filamentous (F) -actin through its binding of monomeric (G) -actin. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.
Synonyms
Profilin-1; Epididymis tissue protein Li 184a; Profilin I; PFN1
Gene Name
PFN1
Gene ID
5216
UniProt
P07737
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Profilin 1, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Expressed in epididymis (at protein level) . .
Applications
Flow Cytometry
Field of Research
Actin, Actin Assembly, Actin, etc., Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Cell Type Marker, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Neuron Marker, Neuroscience, Oncoproteins/Suppressors, Signal Transduction, Subcellular Markers, Synapse Marker, Tags & Cell Markers, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. .
References & Citations
1. Entrez Gene: PFN1 profilin 1 2. Kwiatkowski, D. J., Aklog, L., Ledbetter, D. H., Morton, C. C. Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome. Am. J. Hum. Genet. 46: 559-567, 1990. 3. Mockrin, S. C., Korn, E. D. Acanthamoeba profilin interacts with G-actin to increase the rate of exchange of actin-bound adenosine 5-prime-triphosphate. Biochemistry 19: 5359-5362, 1980.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
15054 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Profilin-1
Subcellular Location
Cytoplasm, cytoskeleton.
Sequence Similarities
Contains 1 PAC (PAS-associated C-terminal) domain.
Protein Name
Profilin-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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