Anti-Sex Hormone Binding Globulin/SHBG Antibody Picoband® Fluoro488 Conjugated

Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones, androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.

Sex hormone-binding globulin; SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin; SHBG

E.coli-derived human SHBG recombinant protein (Position: L30-A210) . Human SHBG shares 72% amino acid (aa) sequence identity with both mouse and rat SHBG.

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

1. Hammond GL (2011) . Diverse Roles for Sex Hormone-Binding Globulin in Reproduction. Biology of Reproduction 85 (3) : 431–441. 2. Selva, D. M., Hogeveen, K. N., Innis, S. M., Hammond, G. L. Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J. Clin. Invest. 117: 3979-3987, 2007. 3. Simó R, Barbosa-Desongles A, Hernandez C, Selva DM (November 2012) . IL1β down-regulation of sex hormone-binding globulin production by decreasing HNF-4α via MEK-1/2 and JNK MAPK pathways. Mol. Endocrinol. 26 (11) : 1917–27.