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Anti-MBD2 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene. It is mapped to 18q21.2. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

Synonyms

Methyl-CpG-binding domain protein 2; Demethylase; DMTase; Methyl-CpG-binding protein MBD2; MBD2

Gene Name

MBD2

Gene ID

8932

UniProt

Q9UBB5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human MBD2 recombinant protein (Position: W159-A411) . Human MBD2 shares 98% amino acid (aa) sequence identity with mouse MBD2.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain, heart, kidney, stomach, testis and placenta. .

Applications

Flow Cytometry

Field of Research

2339, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. .

References & Citations

1. Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (September 1999) . Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. Mamm Genome 10 (9) : 906–12. 2. Hendrich, B., Bird, A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Molec. Cell. Biol. 18: 6538-6547, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

43255 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Methyl-CpG-binding domain protein 2

Subcellular Location

Nucleus . Nuclear, in discrete foci. Detected at replication foci in late S phase.

Sequence Similarities

Contains 1 MBD (methyl-CpG-binding) domain.

Protein Name

Methyl-CpG-binding domain protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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