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Anti-Von Willebrand Factor/VWF Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Von Willebrand factor (VWF) is a blood glycoprotein involved in hemostasis. It is mapped to 12p13.31. The VWF gene encodes von Willebrand factor (VWF), a large multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a major mediator of platelet-vessel wall interaction and platelet adhesion, and as a carrier for coagulation factor VIII. VWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix. VWF deficiency or dysfunction (von Willebrand disease) leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels.

Synonyms

Von Willebrand factor; vWF; von Willebrand antigen 2; von Willebrand antigen II; Vwf

Gene Name

VWF

Gene ID

22371

UniProt

Q8CIZ8

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse VWF recombinant protein (Position: M1304-E1452) .

Clonality

Polyclonal

Tissue Specificity

Plasma. Expressed in liver. .

Applications

Flow Cytometry

Field of Research

Serum Proteins, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. .

References & Citations

1. Sadler JE (1998) . Biochemistry and genetics of von Willebrand factor. Annu. Rev. Biochem. 67: 395–424. 2. Ginsburg, D., Handin, R. I., Bonthron, D. T., Donlon, T. A., Bruns, G. A. P., Latt, S. A., Orkin, S. H. Human von Willebrand factor (VWF) : isolation of complementary DNA (cDNA) clones and chromosomal localization. Science 228: 1401-1406, 1985. 3. Sporn, L. A., Marder, V. J., Wagner, D. D. Von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively. Blood 69: 1531-1534, 1987.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

309269 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Von Willebrand factor

Subcellular Location

Secreted . Secreted, extracellular space, extracellular matrix . Localized to storage granules. .

Sequence Similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Protein Name

Von Willebrand factor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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