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Anti-Mitofusin 1/MFN1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is an 80-90 kDa mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN-2, and to undergo ubiquitination by MARCH5. MFN-1 has two key domains. One is a coiled-coil region that mediates MFN-1: MFN-1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression of MFN1 caused perinuclear mitochondrial clustering.

Synonyms

Mitofusin-1;3.6.5.-; Fzo homolog; Transmembrane GTPase MFN1; MFN1

Gene Name

MFN1

Gene ID

55669

UniProt

Q8IWA4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminal of human Mitofusin 1, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. .

Applications

Flow Cytometry

Field of Research

Cancer Susceptibility,2339, Epigenetics and Nuclear Signaling, Transcription, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. .

References & Citations

1. Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993) . 3,400 new expressed sequence tags identify diversity of transcripts in human brain. Nat Genet 4 (3) : 256–67. 2. Meeusen, S., McCaffery, J. M., Nunnari, J. Mitochondrial fusion intermediates revealed in vitro. Science 305: 1747-1752, 2004. 3. Santel, A., Fuller, M. T. Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114: 867-874, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

84100 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Mitofusin-1

Subcellular Location

Mitochondrion outer membrane ; Multi- pass membrane protein .

Sequence Similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.

Protein Name

Mitofusin-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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