Anti-Calretinin/CALB2 Antibody Picoband®

Calretinin, also known as 29 kDa calbindin, is a vitamin D-dependent calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by the CALB2 gene. This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. Calretinin is mapped to 16q22.2. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers.

A synthetic peptide corresponding to a sequence at the C-terminal of human Calretinin, different from the related mouse and rat sequences by one amino acid.

1. Parmentier M.; The human calbindins: cDNA and gene cloning.; Adv. Exp. Med. Biol. 255:233-240 (1989) . 2. Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., Jacobowitz D.M.; The mouse calretinin gene promoter region: structural and functional components.; Brain Res. Mol. Brain Res. 49:175-187 (1997) . 3. Gabrielides C., McCormack A.L., Hunt D.F., Christakos S.; Brain calbindin-D28k and an Mr 29,000 calcium binding protein in cerebellum are different but related proteins: evidence obtained from sequence analysis by tandem mass spectrometry.; Biochemistry 30:656-662 (1991) .

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.