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Anti-IL18 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Interleukin-18

Synonyms

Interleukin-18; IL-18; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Il18; Igif

Gene Name

IL18

Gene ID

16173

UniProt

P70380

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse IL-18 recombinant protein (Position: N36-S192) . Mouse IL-18 shares 66% and 91% amino acid (aa) sequence identity with human and rat IL-18, respectively.

Clonality

Polyclonal

Tissue Specificity

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cancer Metabolism, Cytokines, Immunology, Innate Immunity, Interleukins, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Tumor Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

References & Citations

1. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K (November 1995) . Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378 (6552) : 88–91. 2. Nolan KF, Greaves DR, Waldmann H (July 1998) . The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics 51 (1) : 161–3.. 3. Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor) . 4. Nolan, K. F., Greaves, D. R., Waldmann, H. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics 51: 161-163, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

22135 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin-18

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the IL-15/IL-21 family.

Protein Name

Interleukin-18

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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