Anti-IL15 Antibody Picoband® Fluoro488 Conjugated

Interleukin (IL) -15 is a cytokine with the ability to stimulate the proliferation activity of Th1 and/or Th2 lymphocytes. This gene is mapped to human chromosome 4q31 by fluorescence in situ hybridization. IL-15 is a novel cytokine whose effects on T-cell activation and proliferation are similar to those of interleukin-2 (IL-2), presumably because IL-15 utilizes the beta and gamma chains of the IL-2 receptor. IL-15 can play a role in the initiation and outcome of acute and chronic rejection. Anti-IL-15 therapy in combination with classic immunosuppression therapy might be beneficial in the prevention of acute, and especially chronic, allograft rejection.

E.coli-derived human IL-15 recombinant protein (Position: N49-S162) . Human IL-15 shares 70% amino acid (aa) sequence identity with both mouse and rat IL-15.

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.

Antiviral Signaling, Cancer, Cytokines, Immune System Diseases, Immunology, Innate Immunity, Interleukins, Metabolism, NK Cells, Obesity, Tumor Immunology

Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

1. Anderson, D. M.; Johnson, L.; Glaccum, M. B.; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Valentine, V.; Kirstein, M. N.; Shapiro, D. N.; Morris, S. W.; Grabstein, K.; Cosman, D. Chromosomal assignment and genomic structure of IL15. Genomics 25: 701-706, 1995. 2. Conti F, Frappier J, Dharancy S, Chereau C, Houssin D, Weill B, Calmus Y. Interleukin-15 production during liver allograft rejection in humans. Transplantation. 2003 Jul 15;76 (1) :210-6.