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Anti-HOXA9 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. It is mapped to 7p15.2. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA9 is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. As HOXA9 is part of the homeobox family, involved in setting the body plans of animals, it is likely that HOXA9 would display increased expression in cells with higher differentiation potentials.

Synonyms

Homeobox protein Hox-A9; Homeobox protein Hox-1G; HOXA9; HOX1G

Gene Name

HOXA9

Gene ID

3205

UniProt

P31269

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human HOXA9 recombinant protein (Position: M1-R204) . Human HOXA9 shares 98% amino acid (aa) sequence identity with mouse HOXA9.

Clonality

Polyclonal

Tissue Specificity

Liver.

Applications

Flow Cytometry

Field of Research

Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. .

References & Citations

1. McAlpine PJ, Shows TB (Aug 1990) . Nomenclature for human homeobox genes. Genomics 7 (3) : 460. 2. Scott MP (Dec 1992) . Vertebrate homeobox gene nomenclature. Cell 71 (4) : 551–3. 3. Chisaka O, Capecchi MR (April 1991) . Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350 (6318) : 473–9. 4. Argiropoulos B, Humphries RK (October 2007) . Hox genes in hematopoiesis and leukemogenesis. Oncogene 26 (47) : 6766–76.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

30172 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Homeobox protein Hox-A9

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the Abd-B homeobox family.

Protein Name

Homeobox protein Hox-A9

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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