Anti-HOXA9 Antibody Picoband®

Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. It is mapped to 7p15.2. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA9 is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. As HOXA9 is part of the homeobox family, involved in setting the body plans of animals, it is likely that HOXA9 would display increased expression in cells with higher differentiation potentials.

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. .

1. McAlpine PJ, Shows TB (Aug 1990) . Nomenclature for human homeobox genes. Genomics 7 (3) : 460. 2. Scott MP (Dec 1992) . Vertebrate homeobox gene nomenclature. Cell 71 (4) : 551–3. 3. Chisaka O, Capecchi MR (April 1991) . Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350 (6318) : 473–9. 4. Argiropoulos B, Humphries RK (October 2007) . Hox genes in hematopoiesis and leukemogenesis. Oncogene 26 (47) : 6766–76.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.