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Anti-GDNF Receptor alpha 1/GFRA1 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PB9202-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Synonyms

GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GFRA1; GDNFRA, RETL1, TRNR1

Gene Name

GFRA1

Gene ID

14585

UniProt

P56159

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227) . Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

Clonality

Polyclonal

Tissue Specificity

T-cells and endothelial cells.

Applications

Flow Cytometry

Field of Research

Growth and Development, Neurology Process, Neuroscience

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) . .

References & Citations

1. Gorodinsky A, Zimonjic DB, Popescu NC, Milbrandt J (March 1998) . Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. Cytogenet Cell Genet 78 (3-4) : 289–90. 2. Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, Fox GM, Chakravarti A (June 1998) . Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. Genomics 48 (3) : 354–62. 3. Entrez Gene: GFRA1 GDNF family receptor alpha 1

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51456 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

GDNF family receptor alpha-1

Subcellular Location

Cell membrane ; Lipid-anchor, GPI-anchor .

Sequence Similarities

Belongs to the glutamate--cysteine ligase type 3 family.

Protein Name

GDNF family receptor alpha-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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