Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-GDNF Receptor alpha 1/GFRA1 Antibody Picoband®

Boster Bio Anti-GDNF Receptor alpha 1/GFRA1 Antibody Picoband® catalog # PB9202. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Synonyms

GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GFRA1; GDNFRA, RETL1, TRNR1

Gene Name

GFRA1

Gene ID

14585

UniProt

P56159

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227) . Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

Clonality

Polyclonal

Tissue Specificity

T-cells and endothelial cells.

Applications

IHC, WB

Field of Research

Growth and Development, Neurology Process, Neuroscience

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) . .

References & Citations

1. Gorodinsky A, Zimonjic DB, Popescu NC, Milbrandt J (March 1998) . Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. Cytogenet Cell Genet 78 (3-4) : 289–90. 2. Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, Fox GM, Chakravarti A (June 1998) . Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. Genomics 48 (3) : 354–62. 3. Entrez Gene: GFRA1 GDNF family receptor alpha 1

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

51456 MW

Observed Molecular Weight

51 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

GDNF family receptor alpha-1

Subcellular Location

Cell membrane ; Lipid-anchor, GPI-anchor .

Sequence Similarities

Belongs to the glutamate--cysteine ligase type 3 family.

Protein Name

GDNF family receptor alpha-1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Rat Parathyroid Hormone (PTH) ELISA Kit
abx514255 96 Well

Rat Parathyroid Hormone (PTH) ELISA Kit

Sign In for Pricing
View Details
MPRIP Human Gene Knockout Kit (CRISPR)
KN211386LP 1 Kit

MPRIP Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
ERCC1 3'UTR Luciferase Stable Cell Line
TU007000 1.0 mL

ERCC1 3'UTR Luciferase Stable Cell Line

Sign In for Pricing
View Details
Histidine Rich Glycoprotein (Biotin)
547530 200 µL

Histidine Rich Glycoprotein (Biotin)

Sign In for Pricing
View Details
Volinanserin 50mg
A17115-50 50 mg

Volinanserin 50mg

Sign In for Pricing
View Details
Mouse Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) ELISA Kit
abx528727 96 Tests

Mouse Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) ELISA Kit

Sign In for Pricing
View Details