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Anti-HOXA10 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene. HOXA10 is expressed in the adult human endometrium, and the expression of HOXA10 dramatically increased during the midsecretory phase of the menstrual cycle, corresponding to the time of implantation and increase in circulating progesterone. HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human. HOXA10 is also a master regulator of postnatal hematopoietic development whose tight regulation is required for normal development of erythroid and megakaryocytic lineages.

Synonyms

Homeobox protein Hox-A10; Homeobox protein Hox-1.8; Homeobox protein Hox-1H; PL; HOXA10; HOX1H

Gene Name

HOXA10

Gene ID

3206

UniProt

P31260

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human HOXA10 recombinant protein (Position: Y57-R340) . Human HOXA10 shares 87% amino acid (aa) sequence identity with mouse HOXA10.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

References & Citations

1. McAlpine PJ, Shows TB (Aug 1990) . Nomenclature for human homeobox genes. Genomics 7 (3) : 460. 2. Scott MP (Dec 1992) . Vertebrate homeobox gene nomenclature. Cell 71 (4) : 551–3. 3. Taylor, H. S., Arici, A., Olive, D., Igarashi, P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J. Clin. Invest. 101: 1379-1384, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

42414 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Homeobox protein Hox-A10

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the Abd-B homeobox family.

Protein Name

Homeobox protein Hox-A10

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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