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Anti-HOXA11 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene. It is mapped to 7p15.2. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is involved in the regulation of uterine development and is required for female fertility. HOXA11 is essential for the development of the uterosacral ligaments, it has been found that women with pelvic organ prolapse may have weakened connective tissue due to changes in this signaling pathway. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.

Synonyms

Homeobox protein Hox-A11; Homeobox protein Hox-1I; HOXA11; HOX1I

Gene Name

HOXA11

Gene ID

3207

UniProt

P31270

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human HOXA11 recombinant protein (Position: H74-R245) . Human HOXA11 shares 95% amino acid (aa) sequence identity with mouse HOXA11.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

References & Citations

1. McAlpine PJ, Shows TB (Aug 1990) . Nomenclature for human homeobox genes. Genomics 7 (3) : 460. 2. Scott MP (Dec 1992) . Vertebrate homeobox gene nomenclature. Cell 71 (4) : 551–3. 3. Entrez Gene: HOXA11 homeobox A11

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

34486 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Homeobox protein Hox-A11

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the Abd-B homeobox family.

Protein Name

Homeobox protein Hox-A11

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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