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Anti-GATA5 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Transcription factor GATA-5, also named GATAS or GATA5, is a protein that in humans is encoded by the GATA5 gene. It is mapped to 20q13.33. The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. In addition, the expression of GATA5 increased in a human colon cancer cell line within 2 hours of exposure to sodium butyrate, which induces differentiation.

Synonyms

Transcription factor GATA-5; GATA-binding factor 5; GATA5

Gene Name

GATA5

Gene ID

140628

UniProt

Q9BWX5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GATA5 recombinant protein (Position: M1-A397) . Human GATA5 shares 75% amino acid (aa) sequence identity with mouse GATA5.

Clonality

Polyclonal

Tissue Specificity

T-cells and endothelial cells.

Applications

Flow Cytometry

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Transcription, Zinc Finger

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcription factor required during cardiovascular development (PubMed:23289003) . Plays an important role in the transcriptional program (s) that underlies smooth muscle cell diversity (By similarity) . Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888) . .

References & Citations

1. Gao, X., Sedgwick, T., Shi, Y.-B., Evans, T. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Molec. Cell. Biol. 18: 2901-2911, 1998. 2. Entrez Gene: GATA5 GATA binding protein 5

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41299 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Transcription factor GATA-5

Subcellular Location

Nucleus .

Sequence Similarities

Contains 2 GATA-type zinc fingers.

Protein Name

Transcription factor GATA-5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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