Anti-MUM1/IRF4 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.
Synonyms
Interferon regulatory factor 4; IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5; IRF4; MUM1
Gene Name
IRF4
Gene ID
3662
UniProt
Q15306
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human MUM1 recombinant protein (Position: E272-E451) . Human MUM1 shares 92% amino acid (aa) sequence identity with mouse MUM1.
Clonality
Polyclonal
Tissue Specificity
Lymphoid cells.
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Susceptibility, Cell Type Markers, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Tags & Cell Markers, Transcription, Transcription Factors, Tumor Associated
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8 (+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity) . .
References & Citations
1. Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., Zeng, Y., Chen, B., Epstein, J., Staudt, L. M. IRF4 addiction in multiple myeloma. Nature 454: 226-231, 2008. 2. Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997) . Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25. Genomics 37 (2) : 229–33. 3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008) . Novel MITF targets identified using a two-step DNA microarray strategy. Pigment Cell Melanoma Res. 21 (6) : 665–76.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
51772 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Interferon regulatory factor 4
Subcellular Location
Nucleus.
Sequence Similarities
Belongs to the IRF family.
Protein Name
Interferon regulatory factor 4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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