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Anti-GATA3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Trans-acting T-cell-specific transcription factor GATA-3, also named HDR or GATA3, is a protein that in humans is encoded by the GATA3 gene. It is mapped to 10p14. This gene belongs to the GATA family of transcription factors. It regulates luminal epithelial cell differentiation in the mammary gland. The protein contains two GATA-type zinc fingers, it is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells, and induces the differentiation of Th0 cells towards this T cell subtype while suppressing their differentiation towards Th1 cells.

Synonyms

Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3; GATA3

Gene Name

GATA3

Gene ID

2625

UniProt

P23771

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GATA3 recombinant protein (Position: M1-E197) . Human GATA3 shares 95% amino acid (aa) sequence identity with mouse GATA3.

Clonality

Polyclonal

Tissue Specificity

T-cells and endothelial cells.

Applications

Flow Cytometry

Field of Research

Lineage Specification, Non-CD, Stem Cells, T Cells, Transcription, Zinc Finger

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. .

References & Citations

1. Joulin V, Bories D, Eleouet JF, Labastie MC, Chretien S, Mattei MG, Romeo PH (Jul 1991) . A T-cell specific TCR delta DNA binding protein is a member of the human GATA family 2. Kouros-Mehr Hosein, Slorach EM, Sternlicht MD, Werb Z (December 2006) . GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127 (5) : 1041–55. 3. Wilson BJ (2008) . Does GATA3 act in tissue-specific pathways? A meta-analysis-based approach. J. Carcinogenesis 7: 6.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

47916 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Trans-acting T-cell-specific transcription factor GATA-3

Subcellular Location

Nucleus.

Sequence Similarities

Contains 2 GATA-type zinc fingers.

Protein Name

Trans-acting T-cell-specific transcription factor GATA-3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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