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Anti-Glucose 6 Phosphate Dehydrogenase/G6PD Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PB9198-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Glucose-6-phosphate dehydrogenase, also known as G6PD or G6PDH, is an enzyme that in humans is encoded by the G6PD gene. It is mapped to Xq28. G6PD plays a key role in the production of ribose 5-phosphate and the generation of NADPH in the hexose monophosphate pathway. Because this pathway is the only NADPH-generation process in mature red cells, which lack the citric adid cycle, a genetic deficiency of G6PD is often associated with adverse physiologic effects. It has been found that aldosterone decreased G6PD expression and activity, resulting in increased oxidant stress and decreased nitric oxide levels, similar to what is observed in G6PD-deficient endothelial cells.

Synonyms

Glucose-6-phosphate 1-dehydrogenase; G6PD;1.1.1.49; G6PD

Gene Name

G6PD

Gene ID

2539

UniProt

P11413

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human G6PD recombinant protein (Position: E315-L515) . Human G6PD shares 95% and 96% amino acid (aa) sequences identity with mouse and rat G6PD, respectively.

Clonality

Polyclonal

Tissue Specificity

Isoform Long is found in lymphoblasts, granulocytes and sperm.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cancer, Cancer Metabolism, Carbohydrate Metabolism, Cardiovascular, Diabetes, Diabetes-associated, Energy Metabolism, Energy Transfer Pathways, Heart Disease, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. .

References & Citations

1. Aster J, Kumar V, Robbins SL, Abbas AK, Fausto N, Cotran RS (2010) . Robbins and Cotran pathologic basis of disease. Saunders/Elsevier. pp. Kindle Locations 33340–33341. 2. Takizawa, T., Huang, I.-Y., Ikuta, T., Yoshida, A. Human glucose-6-phosphate dehydrogenase: primary structure and cDNA cloning. Proc. Nat. Acad. Sci. 83: 4157-4161, 1986.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

59257 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Glucose-6-phosphate 1-dehydrogenase

Subcellular Location

Cytoplasm, cytosol. Nucleus. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.

Sequence Similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Protein Name

Glucose-6-phosphate 1-dehydrogenase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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