Anti-KLF6 Antibody Picoband®

Krueppel-like factor 6 (KLF6) is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene which is located on 10p15.1. This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.

Krueppel-like factor 6; B-cell-derived protein 1; Core promoter element-binding protein; GC-rich sites-binding factor GBF; Proto-oncogene BCD1; Suppressor of tumorigenicity 12 protein; Transcription factor Zf9; KLF6; BCD1, COPEB, CPBP, ST12

E.coli-derived human KLF6 recombinant protein (Position: E38-N205) . Human KLF6 shares 92% and 90% amino acid (aa) sequences identity with mouse and rat KLF6, respectively.

Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Krueppel Like Factor, Stem Cells, Transcription, Zinc Finger

1. Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Apr 1998) . Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization. Genomics 48 (1) : 143–4. 2. Li D; Yea S; Dolios G et al. (October 2005) . Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation. Cancer Res. 65 (20) : 9216–25. 3. Entrez Gene: KLF6 Kruppel-like factor 6

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.