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Anti-EDA Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Ectodysplasin-A is a protein that in humans is encoded by the EDA gene. It is mapped to Xq13.1. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia.

Synonyms

Ectodysplasin-A; Ectodermal dysplasia protein; EDA protein; Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form; EDA; ED1, EDA2

Gene Name

EDA

Gene ID

1896

UniProt

Q92838

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human EDA recombinant protein (Position: A30-S391) . Human EDA shares 95% amino acid (aa) sequence identity with mouse EDA.

Clonality

Polyclonal

Tissue Specificity

Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. .

Applications

Flow Cytometry

Field of Research

Developmental Biology, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.

References & Citations

1. Bayes, M., Hartung, A. J., Ezer, S., Pispa, J., Thesleff, I., Srivastava, A. K., Kere, J. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum. Molec. Genet. 7: 1661-1669, 1998. 2. Kere J, Srivastava AK, Montonen O, Zonana J, Thomas N, Ferguson B, Munoz F, Morgan D, Clarke A, Baybayan P, Chen EY, Ezer S, Saarialho-Kere U, de la Chapelle A, Schlessinger D (Sep 1996) . X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet 13 (4) : 409–16.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41294 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ectodysplasin-A

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Protein Name

Ectodysplasin-A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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