What sizes are available for Anti-gamma Catenin/JUP Antibody Picoband® Fluoro647 Conjugated?

Anti-gamma Catenin/JUP Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Anti-gamma Catenin/JUP Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-gamma Catenin/JUP Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-gamma Catenin/JUP Antibody Picoband® Fluoro647 Conjugated is PB9185-Fluoro647.

Selected Variant

PB9185-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Junction plakoglobin (JUP), also known as gamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to β -catenin, and it is mapped to 17q21.2. This gene encodes a major cytoplasmic protein that is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins. Meanwhile, JUP may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes.

Synonyms

Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3; JUP; CTNNG, DP3

Gene Name

JUP

Gene ID

3728

UniProt

P14923

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human gamma Catenin recombinant protein (Position: M556-A745) . Human gamma Catenin shares 98% amino acid (aa) sequence identity with both mouse and rat gamma Catenin.

Clonality

Polyclonal

Tissue Specificity

Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. .

Applications

Flow Cytometry

Field of Research

Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity) . .

References & Citations

1. Kolligs, F. T.; Kolligs, B.; Hajra, K. M.; Hu, G.; Tani, M.; Cho, K. R.; Fearon, E. R. : Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev. 14: 1319-1331, 2000. 2. Entrez Gene: JUP junction plakoglobin

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

81745 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Junction plakoglobin

Subcellular Location

Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form.

Sequence Similarities

Belongs to the beta-catenin family.

Protein Name

Junction plakoglobin

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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