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Anti-CD79b Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene. By fluorescence in situ hybridization, It is mapped to 17q23.3. The CD79B protein together with the related CD79A protein, forms a dimer associated with membrane bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR) which is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig) . CD79b also can enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Synonyms

B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD79b; CD79B; B29, IGB

Gene Name

CD79B

Gene ID

974

UniProt

P40259

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CD79b recombinant protein (Position: A29-E229) . Human CD79b shares 70% amino acid (aa) sequence identity with mouse CD79b.

Clonality

Polyclonal

Tissue Specificity

B-cells.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, B Cells, Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. .

References & Citations

1. Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta 2. Dobbs, A. K., Yang, T., Farmer, D., Kager, L., Parolini, O., Conley, M. E. Cutting edge: a hypomorphic mutation in Ig-beta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development. J. Immun. 179: 2055-2059, 2007. 3. Wood, W. J., Jr., Thompson, A. A., Korenberg, J., Chen, X., May, W., Wall, R., Denny, C. T. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB) . Genomics 16: 187-192, 1993.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

26 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

B-cell antigen receptor complex-associated protein beta chain

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .

Sequence Similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein Name

B-cell antigen receptor complex-associated protein beta chain

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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