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Anti-Csk Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

CSK also known as C-Src kinase, is a non-receptor protein tyrosine kinase protein that in humans is encoded by the CSK gene. It is mapped to 15q24.1. CSK suppresses activity of the Src family of protein kinases by phosphorylation of Src family members at a conserved C-terminal site in Src. Csk's control of the Src family activity is widely thought to be central to regulation of the immune response. CSK can downregulate tyrosine kinase activity of the SRC oncoprotein through tyrosine phosphorylation of the SRC carboxy terminus. Since cell transformation by SRC oncoproteins is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene.

Synonyms

Tyrosine-protein kinase CSK;2.7.10.2; C-Src kinase; Protein-tyrosine kinase CYL; CSK

Gene Name

CSK

Gene ID

1445

UniProt

P41240

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CSK recombinant protein (Position: S2-G204) . Human CSK shares 99% amino acid (aa) sequence identity with both mouse and rat CSK.

Clonality

Polyclonal

Tissue Specificity

Expressed in lung and macrophages. .

Applications

Flow Cytometry

Field of Research

Protein Phosphorylation, Signal Transduction, Tyrosine Kinases

Purification

Immunogen affinity purified.

Form

Liquid

Function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. .

References & Citations

1. Bergman M, Mustelin T, Oetken C, Partanen J, Flint NA, Amrein KE, Autero M, Burn P, Alitalo K (August 1992) . The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. 2. Sun G, Budde RJ (September 1997) . Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system. Arch. Biochem. Biophys. 345 (1) : 135–42. 3. Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H (May 1991) . Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 351 (6321) : 69–72.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50704 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tyrosine-protein kinase CSK

Subcellular Location

Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.

Protein Name

Tyrosine-protein kinase CSK

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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