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Anti-CD43/SPN Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

CD43, also known as leukosialin or sialophorin, is a transmembrane cell surface protein that in humans is encoded by the SPN gene. It is mapped to 16p11.2. It is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which is important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome, suggesting that CD43 have a role in T-cell activation. T-cell activation requires the removal of CD43 from the immunologic synapse to allow efficient engagement of the TCR with molecules on the APC.

Synonyms

Leukosialin; Galactoglycoprotein; GALGP; Leukocyte sialoglycoprotein; Sialophorin; CD43; SPN; CD43

Gene Name

SPN

Gene ID

6693

UniProt

P16150

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CD43 recombinant protein (Position: A272-P400) . Human CD43 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat CD43, respectively.

Clonality

Polyclonal

Tissue Specificity

Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Applications

Flow Cytometry

Field of Research

Apoptosis, Cell Biology, Cell Type Markers, Hematopoietic Progenitors, Immunology, Intracellular, Lymphoid, Myeloid, Stem Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Form

Liquid

Function

One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity) . During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity) . .

References & Citations

1. Fukuda M, Carlsson SR (1987) . Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens.. Med. Biol. 64 (6) : 335–43. 2. Rogaev EI, Keryanov SA (1993) . Unusual variability of the complex dinucleotide repeat block at the SPN locus.. Hum. Mol. Genet. 1 (8) : 657. 3. Rosenstein Y, Park JK, Hahn WC, et al. (1992) . CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1.. Nature 354 (6350) : 233–5.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40322 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Leukosialin

Subcellular Location

Membrane; Single-pass type I membrane protein.

Sequence Similarities

Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Protein Name

Leukosialin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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