DUB-IN-3

DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC50 value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease[1].

Product Specifications

CAS Number

[924296-17-3]

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/DUBs-IN-3.html

Concentration

10mM

Purity

99.00

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

C=CCO/N=C1C2=C(N=C(C#N)C(C#N)=N2)C3=CC=CC=C/13

Molecular Formula

C16H9N5O

Molecular Weight

287.28

Precautions

H228, H315, H319

References & Citations

[1]Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5 (4) :552-8.