MERS-CoV-IN-2
MERS-CoV-IN-2 (compound 3c) is a MERS-CoV 3CLpro inhibitor (IC50=17nM) . MERS-CoV-IN-2 inhibits the activity of the 3CLpro enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV[1].
Product Specifications
UNSPSC
12352211
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mers-cov-in-2.html
Smiles
O=C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC(C)C)OC[C@@H](N2CC3=CC=CC(Cl)=C3)CCC2=O
Molecular Formula
C26H35ClN4O6
Molecular Weight
535.03
References & Citations
[1]Dampalla, et al. Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. Journal of Medicinal Chemistry (2024) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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