MERS-CoV-IN-2

MERS-CoV-IN-2 (compound 3c) is a MERS-CoV 3CLpro inhibitor (IC50=17nM) . MERS-CoV-IN-2 inhibits the activity of the 3CLpro enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV[1].

Product Specifications

UNSPSC

12352211

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mers-cov-in-2.html

Smiles

O=C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC(C)C)OC[C@@H](N2CC3=CC=CC(Cl)=C3)CCC2=O

Molecular Formula

C26H35ClN4O6

Molecular Weight

535.03

References & Citations

[1]Dampalla, et al. Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. Journal of Medicinal Chemistry (2024) .