What is the catalog number for BMP-2, Human/Mouse/Rat?

The catalog number for BMP-2, Human/Mouse/Rat is HY-P7006.

What sizes are available for BMP-2, Human/Mouse/Rat?

BMP-2, Human/Mouse/Rat is available in the following size(s): 10 µg, 50 µg, 100 µg, 500 µg, 1 mg.

How many pack sizes does BMP-2, Human/Mouse/Rat come in?

BMP-2, Human/Mouse/Rat is available in 5 different pack sizes.

Is BMP-2, Human/Mouse/Rat in stock?

BMP-2, Human/Mouse/Rat is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures BMP-2, Human/Mouse/Rat?

BMP-2, Human/Mouse/Rat is manufactured by QuantiMol.

What is the estimated delivery time for BMP-2, Human/Mouse/Rat?

Estimated delivery time for BMP-2, Human/Mouse/Rat is approximately 15 business day(s), depending on your location.

BMP-2, Human/Mouse/Rat

Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TNFβ family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification[1]. BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes[2]. BMP-2 is the junction between atherosclerotic vascular calcification and normal bone formation mechanism[3]. BMP-2 Protein, Human/Mouse/Rat is 114 a.a. (Q283-R396), expressed in E. coli.

Product Specifications

Product Name Alternative

BMP-2 Protein, Human/Mouse/Rat, Human; Mouse; Rat, E. coli

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/bmp-2-protein-human-mouse-rat.html

Purity

96.70

Smiles

QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Molecular Formula

650 (Gene_ID) P12643 (Q283-R396) (Accession)

Molecular Weight

Approximately 13 kDa under reduced (R) conditions, 26 kDa under non reducing (N) conditions, based on SDS-PAGE.

References & Citations

[1]Yang P, et al. The role of bone morphogenetic protein signaling in vascular calcification. Bone. 2020 Dec;141:115542.|[2]Miyazawa K, et al. Regulation of TGF-β Family Signaling by Inhibitory Smads. Cold Spring Harb Perspect Biol. 2017 Mar 1;9 (3) :a022095.|[3]Simões Sato AY, et al. BMP-2 and -4 produced by vascular smooth muscle cells from atherosclerotic lesions induce monocyte chemotaxis through direct BMPRII activation. Atherosclerosis. 2014 Jul;235 (1) :45-55.|[4]Boström K, et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993 Apr;91 (4) :1800-9.|[5]Mohler ER 3rd, et al. Bone formation and inflammation in cardiac valves. Circulation. 2001 Mar 20;103 (11) :1522-8.|[6]Demer LL, et al. Mechanism of calcification in atherosclerosis. Trends Cardiovasc Med. 1994 Jan-Feb;4 (1) :45-9.|[7]David L, et al. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev. 2009 Jun;20 (3) :203-12.|[8]Liberman M, et al. Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem Biophys Res Commun. 2011 Sep 30;413 (3) :436-41.|[9]Hoodless PA, et al. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell. 1996 May 17;85 (4) :489-500.|[10]Bai Y, et al. BMP-2, VEGF and bFGF synergistically promote the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. Biotechnol Lett. 2013 Mar;35 (3) :301-8.