EM-12-Alkyne-C6-OMs
EM-12-Alkyne-C6-OMs is a conjugate of E3 ligase ligand and linker, consisting of 2- (2,6-Dioxopiperidin-3-yl) phthalimidine (EM-12) and the corresponding Linker (HY-159018). EM-12-Alkyne-C6-OMs can be used to synthesize PROTACs[1].
Product Specifications
CAS Number
2570254-42-9
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/em-12-alkyne-c6-oms.html
Smiles
O=C1N(CC2=C1C=CC=C2C#CCCCCCCOS(C)(=O)=O)C(C(N3)=O)CCC3=O
Molecular Formula
C22H26N2O6S
Molecular Weight
446.52
References & Citations
[1]Zhu X, et al. Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation. Cell Chem Biol. 2022 Nov 17;29 (11) :1616-1629.e12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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