Schisandrone

Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera[1]. Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia[2].

Product Specifications

CAS Number

[98619-25-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CD74

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/schisandrone.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1[C@@H](C)[C@@H](C)[C@H](C2=CC=C(OC)C(OC)=C2)C3=C1C=C(O)C(OC)=C3

Molecular Formula

C21H24O5

Molecular Weight

356.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lian-niang, L., et al. Schisandrone, a New 4-Aryltetralone Lignan fromSchisandra sphenanthera. Planta Medica, 1985, 51 (03), 217–219.|[2]Qi Y, et al. An inhibitory effect of schisandrone on -hemolysin expression to combat methicillin-resistant staphylococcus aureus infections. World J Microbiol Biotechnol. 2022 Nov 8;39 (1) :3.