PROTAC CYP1B1 degrader-2
PROTAC CYP1B1 degrader-2 (compound PV2) is a von Hippel-Landau (VHL) E3 ligase-based CYP1B1 degrader with the DC50 of 1.0 nM at 24 h in A549/Taxol cells. PROTAC CYP1B1 degrader-2 inhibits growth, migration, and invasion of A549/Taxol cell (Sturcture Note: (Blue: VHL ligand , Black: linker (HY-W007700), Pink: CYP1B1 ligand (HY-159006).
Product Specifications
CAS Number
2836297-26-6
UNSPSC
12352005
Target
Cytochrome P450; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-cyp1b1-degrader-2.html
Smiles
CC(C)([C@@H](C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)NC(CCCCCCCOC4=CC=CC=C4C5=CSC(C6=CSC(NC7=CC=C(Cl)C=C7)=N6)=N5)=O)C
Molecular Formula
C49H56ClN7O5S3
Molecular Weight
954.66
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
Frequently Asked Questions
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