INH14

INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].

Product Specifications

CAS Number

[200134-22-1]

Product Name Alternative

2-APV; DL-2-Amino-5-phosphonovaleric acid,D-APV; D-2-Amino-5-phosphonovaleric acid

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H410

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/INH14.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(NC1=CC=CC=C1)NC2=CC=C(CC)C=C2

Molecular Formula

C15H16N2O

Molecular Weight

240.30

Precautions

H302, H319, H372, H410

References & Citations

[1]Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20 (5) :710-717.