INH14
Product Specifications
Product Name Alternative
2-APV; DL-2-Amino-5-phosphonovaleric acid,D-APV; D-2-Amino-5-phosphonovaleric acid
UNSPSC Description
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].
Target Antigen
IKK
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/INH14.html
Purity
98.0
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(NC1=CC=CC=C1)NC2=CC=C(CC)C=C2
Molecular Weight
240.30
References & Citations
[1]Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114454/INH14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114454/INH14-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
200134-22-1
Available Sizes
Curated Selection
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