WH-4-023
Product Specifications
Product Name Alternative
Dual LCK/SRC inhibitor
UNSPSC Description
WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.
Target Antigen
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WH-4-023.html
Purity
99.75
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(OC1=C(C)C=CC=C1C)N(C2=CC=C(OC)C=C2OC)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3
Molecular Weight
568.67
References & Citations
[1]Martin MW, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12299/WH-4-023-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12299/WH-4-023-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
837422-57-8
Available Sizes
Curated Selection
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