WH-4-023

WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.

Product Specifications

CAS Number

[837422-57-8]

Product Name Alternative

Dual LCK/SRC inhibitor

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WH-4-023.html

Purity

99.87

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(OC1=C(C)C=CC=C1C)N(C2=CC=C(OC)C=C2OC)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3

Molecular Formula

C32H36N6O4

Molecular Weight

568.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Martin MW, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49 (16) :4981-91.