Oleanolic acid 28-O-β-D-glucopyranoside

Oleanolic acid 28-O-β-D-glucopyranoside (β-D-Glucopyranosyl oleanolate) is an orally active pentacyclic triterpenoid compound. Oleanolic acid 28-O-β-D-glucopyranoside has anti-inflammatory effects. In ulcerative colitis models, Oleanolic acid 28-O-β-D-glucopyranoside can inhibit the inflammatory response, enhance the intestinal epithelial barrier function, and modulate the gut microbiota. Its mechanism of action is related to the PI3K-AKT and MAPK signaling pathways. Oleanolic acid 28-O-β-D-glucopyranoside can be used in the research of diseases such as colitis[1][2].

Product Specifications

CAS Number

[14162-53-9]

Product Name Alternative

β-D-Glucopyranosyl oleanolate

UNSPSC

12352005

Target

Akt; Claudin; COX; Interleukin Related; NO Synthase; p38 MAPK; PI3K

Type

Natural Products

Related Pathways

Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; PI3K/Akt/mTOR

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oleanolic-acid-28-o-β-d-glucopyranoside.html

Purity

99.42

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@](CC[C@]12C)(CCC3(C)C)[C@](C3)([H])C1=CC[C@@]4([H])[C@]2(CC[C@](C(C)5C)([H])[C@@]4(CC[C@@H]5O)C)C)O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]([C@H]6O)CO

Molecular Formula

C36H58O8

Molecular Weight

618.84

References & Citations

[1]A. Marouf, et al. Triterpene Saponins from the Roots of Achyranthes bidentata.|[2]Wang C, et al. Oleanolic acid 28-O-β-D-glucopyranoside: A novel therapeutic agent against ulcerative colitis via anti-inflammatory, barrier-preservation, and gut microbiota-modulation. Biomed Pharmacother. 2024 Nov;180:117534.