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Rhynchophylline (Standard)

Rhynchophylline (Standard) is the analytical standard of Rhynchophylline. This product is intended for research and analytical applications. Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research.[1][2][5][6].

Product Specifications

CAS Number

76-66-4

UNSPSC

12352005

Target

NF-κB; Reference Standards

Type

Reference Standards

Related Pathways

NF-κB; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rhynchophylline-standard.html

Smiles

O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](CC)C4)([H])N4CC3

Molecular Formula

C22H28N2O4

Molecular Weight

384.47

References & Citations

[1]Dan Yuan, et al. Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism. International Immunopharmacology
 Volume 9, Issues 13–14, December 2009, Pages 1549–1554|[2]Houcai Huang, et al. Neuroprotective Effects of Rhynchophylline Against Ischemic Brain Injury via Regulation of the Akt/mTOR and TLRs Signaling Pathways. Molecules 2014, 19 (8) : 11196-11210; doi:10.3390/molecules190811196|[3]Tai-Hyun Kang, et al. Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action. Life Sciences
 Volume 76, Issue 3, 3 December 2004, Pages 331–343|[4]Kinzo Matsumoto, et al. Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: Behavioural and electrophysiological studies. European Journal of Pharmacology
 Volume 517, Issue 3, 11 July 2005, Pages 191–199|[5]Yang Y, et al. Rhynchophylline suppresses soluble Aβ1-42-induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors. Neuropharmacology. 2018 Jun;135:100-112. |[6]Fu AK, et al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111 (27) :9959-64.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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