(Rac) -Indoximod

(Rac) -Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac) -Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].

Product Specifications

CAS Number

[26988-72-7]

Product Name Alternative

1-Methyl-DL-tryptophan; (Rac) -NLG-8189

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rac-indoximod.html

Purity

99.60

Solubility

0.1 M NaOH : 10 mg/mL (ultrasonic) |DMSO : 4.76 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)

Smiles

NC(CC1=CN(C)C2=C1C=CC=C2)C(O)=O

Molecular Formula

C12H14N2O2

Molecular Weight

218.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Jun-Won Lee, et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458 (1-2) :197-205.