CZC-54252 (hydrochloride)
Product Specifications
UNSPSC Description
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity[1].
Target Antigen
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/czc-54252-hydrochloride.html
Purity
98.44
Solubility
DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl
Molecular Weight
541.45
References & Citations
[1]Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0792A/CZC-54252-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0792A/CZC-54252-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1784253-05-9
Available Sizes
Curated Selection
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