BBT
BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ ) -induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway[1].
Product Specifications
CAS Number
445000-45-3
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bbt.html
Purity
99.71
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C1(=CC=C(Br)S1)C(=O)NC1=CC=CC=C1C(C1C=CC=CC=1)=O
Molecular Formula
C18H12BrNO2S
Molecular Weight
386.27
References & Citations
[1]Yao XG, et al. BBT improves glucose homeostasis by ameliorating -cell dysfunction in type 2 diabetic mice. J Endocrinol. 2015 Mar;224 (3) :327-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dedicated for Diverse Library
Clinical Information
No Development Reported
Available Sizes
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