W-13 (hydrochloride)

W-13 hydrochloride is a calmodulin antagonist. W-13 hydrochloride can inhibit Tamoxifen (HY-13757A) -resistant human breast cancer cell growth[1].

Product Specifications

CAS Number

[88519-57-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CaMK

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/w-13-hydrochloride.html

Purity

99.86

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C2C(Cl)=CC=CC2=C1)(NCCCCN)=O.[H]Cl

Molecular Formula

C14H18Cl2N2O2S

Molecular Weight

349.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Tallant EA, et, al. Calmodulin antagonists elevate the levels of 32P-labeled polyphosphoinositides in human platelets. Biochem Biophys Res Commun. 1985 Aug 30;131 (1) :370-7.|[2]Strobl JS, et, al. Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13. J Pharmacol Exp Ther. 1992 Oct;263 (1) :186-93.