NIK-IN-2
NIK-IN-2 (compound 1) is a potent inhibitor of NF-κB-inducing kinase (NIK), with the pIC50 of 7.4. NIK-IN-2 plays an important role in cancer research[1].
Product Specifications
CAS Number
1202763-91-4
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nik-in-2.html
Purity
99.00
Solubility
DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCL)
Smiles
OC(C)(C)C#CC1=CC2=C(NC=C2C3=C(OCCOC)C=NC(N)=N3)C=C1
Molecular Formula
C20H22N4O3
Molecular Weight
366.41
References & Citations
[1]Islam Al-Khawaldeh, et al. An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase. J Med Chem. 2021 Jul 22;64 (14) :10001-10018.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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