Monoclonal Anti-Eribulin Antibody, Rabbit IgG (1M1G11)

Eribulin is a synthetic analogue of the macrocyclic polyether halichondrin B, which was originally isolated from the Asian sea sponge Halichondria okadai. Eribulin binds specifically to the β-tubulin subunit on the (+) end of the microtubule and potently inhibits elongation of the formed microtubule, while having little or no effect on microtubule depolymerization. Eribulin's potent antimitotic activity and nonmitotic effects on tumor biology make it an interesting candidate for investigation as a MTA payload for ADCs.

Product Specifications

Background

CAS Number

9007-83-4

Host

HEK293

Origin Species

Rabbit

Target

Eribulin

Conjugation

Unconjugated

Tag

Rabbit IgG | Rabbit Kappa

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles.

Purity

90%

Bioactivity

Immobilized Monoclonal Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-MY2012b) at 1 μg/mL (100 μL/well) can bind Farletuzumab Ecteribulin diluted with 100% Mouse Serum with a linear range of 0.02-1.25 μg/mL (Routinely tested).