Deserpidine (hydrochloride)

Deserpidine hydrochloride (Harmonyl hydrochloride) is an antihypertensive compound that competitively inhibits the activity of angiotensin converting enzyme (ACE) . Deserpidine hydrochloride competes with angiotensin I for ACE, preventing the conversion of angiotensin I to angiotensin II, thereby lowering blood pressure. Deserpidine hydrochloride can also reduce angiotensin II-induced aldosterone secretion from the adrenal cortex[1].

Product Specifications

CAS Number

[6033-69-8]

Product Name Alternative

Harmonyl (hydrochloride)

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/deserpidine-hydrochloride.html

Smiles

COC([C@H]1[C@@]2([H])C[C@]3([H])C4=C(CCN3C[C@@]2([H])C[C@H]([C@@H]1OC)OC(C5=CC(OC)=C(C(OC)=C5)OC)=O)C6=CC=CC=C6N4)=O.Cl

Molecular Formula

C32H39ClN2O8

Molecular Weight

615.11

References & Citations

[1]Varchi G, et al. Synthesis of deserpidine from reserpine. J Nat Prod. 2005 Nov;68 (11) :1629-31.|[2]Zhang H, et al. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877 (27) :3221-5.|[3]Fulton SC, et al. Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines. Fed Proc. 1976 Dec;35 (14) :2558-62.|[4]Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study