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Carbimazole (Standard)

Carbimazole (Standard) is the analytical standard of Carbimazole. This product is intended for research and analytical applications. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research[1][2][3].

Product Specifications

CAS Number

22232-54-8

UNSPSC

12352005

Target

P38 MAPK; Reference Standards

Type

Reference Standards

Related Pathways

MAPK/ERK Pathway; Others

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/carbimazole-standard.html

Smiles

O=C(N1C=CN(C)C1=S)OCC

Molecular Formula

C7H10N2O2S

Molecular Weight

186.23

References & Citations

[1]Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10 (6) : p. 637-48.|[2]Lehane C, et al. Carbimazole is an inhibitor of protein synthesis and protects from neuronal hypoxic damage in vitro. J Pharmacol Exp Ther. 2013 Dec;347 (3) :781-93.|[3]H. Saeed, et al. Effects of Dose Level of Anti-thyroid Drug Carbimazole on Thermoregulation and Blood Constituents in Male Rabbits (Oryctolagus cuniculus) . Advances in Research, 2014, 2 (3), 129–144.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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