4-Hydroxyantipyrine

4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2].

Product Specifications

CAS Number

[1672-63-5]

Product Name Alternative

4-Hydroxyphenazone; NSC 174055

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-hydroxyantipyrine.html

Purity

99.9

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1O

Molecular Formula

C11H12N2O2

Molecular Weight

204.23

Precautions

H315, H319, H335

References & Citations

[1]Ohkawa Y, et al. Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter. Biol Pharm Bull. 2001 May;24 (5) :529-34.|[2]Ohkawa Y, et al. Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. Biol Pharm Bull. 2001 Dec;24 (12) :1404-10.