Momordicine I

Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the PI3K/Akt pathway, reducing oxidative stress and inflammation. Momordicine I inhibits AKT1, IL-6, and SRC, suggesting its potential application in type 2 diabetes[1][2][3][4][5].

Product Specifications

CAS Number

[91590-76-0]

UNSPSC

12352211

Target

Akt; AMPK; Apoptosis; Autophagy; c-Met/HGFR; DGK; Endogenous Metabolite; Interleukin Related; Keap1-Nrf2; Mitochondrial Metabolism; mTOR; NF-κB; NO Synthase; Oxidative Phosphorylation; PI3K; Reactive Oxygen Species (ROS) ; Src; STAT

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/momordicine-i.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

O=C[C@@]([C@@](CC[C@@H]1O)([H])C(C(C)1C)=C[C@@H]2O)(CC[C@@]34C)[C@]2([H])[C@@]3(CC[C@]4([H])[C@H](C)C[C@@H](O)/C=C(C)\C)C

Molecular Formula

C30H48O4

Molecular Weight

472.70

References & Citations

[1]Li H, et al. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Korean J Physiol Pharmacol. 2023 Jan 1;27 (1) :75-84. |[2]Kao PF, et al. Therapeutic Potential of Momordicine I from Momordica charantia: Cardiovascular Benefits and Mechanisms. Int J Mol Sci. 2024 Sep 29;25 (19) :10518.|[3]Kao Y, et al. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. EXCLI J. 2023 Jun 6;22:482-498.|[4]Bandyopadhyay D, et al. Momordicine-I suppresses head and neck cancer growth by modulating key metabolic pathways. Cell Commun Signal. 2024 Dec 18;22 (1) :597.|[5]Niu Y, et al. Comprehensive Studies on the Regulation of Type 2 Diabetes by Cucurbitane-Type Triterpenoids in Momordica charantia L.: Insights from Network Pharmacology and Molecular Docking and Dynamics. Pharmaceuticals (Basel) . 2025 Mar 27;18 (4) :474.